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The authors express appreciation to Diane Nitzki-George, PharmD, MBA, for help with the manuscript.įunding: Sponsorship for the collaboration and resulting article was made possible by a grant from Abbott Laboratories. Hadley has received honoraria from Abbott Laboratories, Agiotech Biocoatings, Altana, Bayer Pharmaceuticals, GE Medical Systems, GlaxoSmithKline, Merck, Ortho-McNeil, Pfizer, sanofiaventis, and Schering-Plough.Īcknowledgments: Strategic Pharmaceutical Associates was solely responsible for uniting a group of physician and pharmacist thought leaders to gain multidisciplinary consensus on prescribing cephalosporins to penicillin-allergic patients diagnosed with a respiratory infection. Pichichero has received honoraria from Abbott Laboratories, GlaxoSmith-Kline, Innovia Medical, Merck, sanofi-aventis, and sanofi pasteur and research support from Abbott Laboratories, GlaxoSmithKline, MedImmune, Merck, sanofi-aventis, sanofi pasteur, and Welch Allyn. Luskin has received consulting fees from Merck, Genentech, Novartis Pharmaceuticals, Schering-Plough, 3M Pharmaceuticals, Abbott Laboratories, sanofi-aventis, AstraZeneca, Critical Therapeutics, Aerocrine, Teva Pharmaceuticals, King Pharmaceuticals, and IVAX research support from Merck, AstraZeneca, sanofi-aventis, and Novartis and honoraria from AstraZeneca, Schering-Plough, and Merck. This structural similarity has led to considerable confusion regarding cross-reactivity of these drugs and the risks for allergic reactions from cephalosporins among penicillin-allergic patients.

May has received honoraria from Abbott Laboratories and sanofi-aventis. Cross-Reactivity with Cephalosporins Penicillin and cephalosporins both contain a -lactam ring. LaPlante declares no conflicts of interest or financial interests in any product or service mentioned in this article, including grants, employment, gifts, stock holdings, or honoraria. Danziger holds stock in Abbott Laboratories and Pfizer and has received honoraria from Abbott Laboratories and Conexus. Benninger has received honoraria from sanofi-aventis, Ortho-Mc-Neill, and Abbott Laboratories. DePestel has received honoraria from Cubist Pharmaceuticals, Wyeth Pharmaceuticals, and Jobson Publishing.